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The primary end point was objective response.Among the 105 patients who had received previous treatment with platinum chemotherapy, the overall response rate was 64% (95% CI, 54%−73%), including 2% complete responses. In addition, the rates of grade 3 and 4 treatment-related toxicity in both trials were significantly lower with nivolumab than with docetaxel. Of note, all patients enrolled in phase III studies of nivolumab had an ECOG performance status of 0 or 1; patients with autoimmune disease, symptomatic interstitial lung disease, or those receiving systemic immunosuppression were excluded from enrollment.

Use our advanced clinical trial search to find NCI-supported cancer clinical trials that are now enrolling patients. The search can be narrowed by location of the trial, type of treatment, name of the drug, and other criteria. General information about clinical trials is also available. Selected patients with locally advanced tumors may benefit from combined modality treatments. In multiple retrospective analyses of clinical trial data, advanced age alone has not been shown to influence response or survival with therapy.

This section describes the latest changes made to this summary as of the date above. In the total population, PFS was not prolonged in the pembrolizumab groups compared with the docetaxel group. The infusion reactions occurred primarily with the first exposure to amivantamab. The administration of the first dose was split over 2 days to minimize this toxicity.

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The primary end point was investigator-assessed overall response.The overall response rate was 63.2% (95% CI, 49.3%–75.6%), as determined independently by investigator and independent review committee assessments. There were 2 out of 36 complete responses by investigator assessment; all responses were deemed partial by the independent review committee. A phase I/II study (ARROW ) enrolled patients with RET fusion−positive solid tumors. Two hundred thirty-three patients had RET fusion−positive NSCLC.

Almost all studies specified that CT scanning was performed following the administration of intravenous contrast material and that a positive test result was defined as the presence of one or more lymph nodes that measured larger than 1 cm on the short-axis diameter. The median prevalence of mediastinal metastasis was 28% (range, 18%–56%). In a second trial , which was designed to show the superiority of erlotinib versus standard second-line whatdoesitmean sorcha faal chemotherapy after disease progression on first-line platinum combination therapy, 424 patients were randomly assigned. There was no difference in the primary end point of OS (median OS, 5.3 months vs. 5.5 months; HR, 0.96; 95% CI, 0.78–1.19). Grade 3 to 4 treatment-related adverse events occurred in 79% of patients who received docetaxel and ramucirumab as compared with 71% of patients who received docetaxel and placebo.